The Hira complex regulates Gli3R-dependent transcription in Hedgehog signaling and medulloblastoma cell growth and migration
Abstract Regulation of the Hedgehog pathway activity may be supported by coactivators and corepresors of its main effectors- Gli transcription factors.While activation processes are well studied, repression mechanisms remain elusive.We identified chromatin remodelling complex Hira Hospital Bedrails to interact with Gli3R protein, showed that its lo