THE HIRA COMPLEX REGULATES GLI3R-DEPENDENT TRANSCRIPTION IN HEDGEHOG SIGNALING AND MEDULLOBLASTOMA CELL GROWTH AND MIGRATION

The Hira complex regulates Gli3R-dependent transcription in Hedgehog signaling and medulloblastoma cell growth and migration

Abstract Regulation of the Hedgehog pathway activity may be supported by coactivators and corepresors of its main effectors- Gli transcription factors.While activation processes are well studied, repression mechanisms remain elusive.We identified chromatin remodelling complex Hira Hospital Bedrails to interact with Gli3R protein, showed that its lo

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Generic Itemset Mining Based on Reinforcement Learning

One of the biggest problems in itemset mining is the requirement of developing a data structure or algorithm, every time a user wants to extract a different type of itemsets.To overcome this, we propose a method, called Generic Itemset Mining based on Reinforcement Learning (GIM-RL), that offers a unified framework to train an agent for extracting

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